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Abstract #16000 Published in IGR 2-3
Optical coherence tomography applied for measurement of nerve fiber layer thickness in normal eyes
Liu X; Ling Y; Luo RChinese Journal of Ophthalmology 2000; 36: 362
OBJECTIVE: To evaluate the efficiency of optical coherence tomography (OCT) for quantifying retinal nerve fiber layer (RNFL) thickness and its reproducibility, and to investigate the difference of RNFL thickness between various groups. METHODS: According to age, 152 eyes of 152 normal subjects were classified into six groups (e.g., ten-year, 20-year group, etc.), and were investigated by OCT to measure RNFL thickness. Each subject had circular scans around the optic nerve with a circle size of 3.46 mm. RNFL thickness was analyzed in the various groups. Intraclass correlation coefficient (ICC) was calculated in 50 eyes of 37 subjects. RESULTS: The mean RNFL thickness of 152 eyes was 90.09 ± 10.81, 140.27 ± 10.60, 85.03 ± 14.01, 140.27 ± 9.70, and 114.11 ± 6.08 μm (temporal, superior, nasal, inferior, and mean of the whole layer), respectively. Least significant difference (LSD-t test was applied for multiple thickness comparisons of the mean and different quadrants among different groups. The results showed that there were significant differences between the 60~ year group and the others, except for the 50~ year group, in the temporal, superior and inferior quadrants, and mean RNFL thickness (p = 0.000-0.019), and between each of the 10~ to 40~ year groups and each of the 50~ to 60~ year groups for mean RNFL thickness (p = 0.000-0.026. ICCs of RNFL thickness measured by OCT were 0.78, 0.66, 0.64, 0.52, and 0.74 (temporal, superior, nasal, inferior, and mean), respectively. CONCLUSIONS: Normal RNFL thickness can be measured accurately by OCT. There are some differences in RNFL thickness between different age groups in normal persons.LA: Chinese
Dr. X. Liu, Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.2 Optical coherence tomography (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
