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Abstract #16001 Published in IGR 2-3
Glutamate in experimental acute elevated intraocular pressure models of rabbits
Wang P; Jiang Y; Huang PChinese Journal of Ophthalmology 2000; 36: 378
OBJECTIVE: To measure the concentration of glutamate (Glu) in the retina of eyes with experimentally elevated intraocular pressure (IOP). METHODS: High-performance liquid chormatography (HPLC) was utilized to measure Glu in the retina. Eighteen rabbits were divided into three groups, each group containing six rabbits. In one eye of each rabbit in group 1, the IOP was elevated to 60 mmHg (1 mmHg = 0.133 kPa) by perfusing the anterior chamber with normal saline maintained for four hours, while the IOP of the other eye was maintained at 20 mmHg by the same method. In group 2, the same experimental method was used, but the elevated IOP was maintained at 30 mmHg. Group 3 was the normal control group without perfusion. RESULTS: High IOP eyes (60 and 30 mmHg) had higher Glu concentration in the retinal tissue than that of the low IOP eyes (20 mmHg) (p < 0.05). CONCLUSION: Elevated IOP induces a higher content of Glu in the retina.LA: Chinese
Dr. P. Wang, Department of Ophthalmology, Xiangya Hospital, Hunan Medical University, Changsha 410008, China
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
