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Abstract #16003 Published in IGR 2-3

The effect of Erigon Breviscapus (Vant.) Hand-Mazz on axoplasmic transport of optic nerve in rats with experimentally elevated intraocular pressure

Zhu Y; Jiang Y; Liu Z
Chinese Journal of Ophthalmology 2000; 36: 289

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OBJECTIVE: To investigate whether Erigeron Breviscapus (Vant.) Hand-Mazz (EBHM) can improve the optic nerve axoplasmic transport in rats with experimentally elevated intraocular pressure (IOP). METHODS: Thirty healthy SD rats were used for the study, an acute elevated IOP model in the right eye was built, and then they were divided randomly into three groups: group A (0 day group) included six rats for retinal ganglion cell (RGC) counting by left superior colliculus retrograde horse radish perkidase labelling; group B, 12 rats divided into EBHM treatment group and control group (six rats in each subgroup) for RGC counting by left superior colliculus retrograde labelling after 20 days; and group C, 12 rats submitted to the same treatment and procedure as group B after 40 days. RESULTS: after zero days of acute elevated IOP, no labelled RGCs were observed. After 30 days of acute elevated IOP, in the control and RBHM subgroups the density of labelled RGCs was (423 ± 220 and 749 ± 294/mm², respectively, the difference between the two subgroups showing statistical significance (p < 0.01). After 40 days of acute elevated IOP, the density of RGCs in the control and EBHM subgroups in group C were 610 ± 315 and 1048 ± 393/mm², respectively, the difference between the two subgroups being statistically significant (p < 0.01). CONCLUSIONS: After 20 and 40 days of acute elevation of IOP, the density of RGCs was obviously higher in the EBHM group than in the control group. It is revealed that EBHM can improve the optic nerve axoplasmic transportation blocked by acute elevation of IOP in rats.LA: Chinese

Dr. Y. Zhu, Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University, Changsha 41011, China

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Classification:

11.8 Neuroprotection (Part of: 11 Medical treatment)

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