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Abstract #16877 Published in IGR 9-1
Relation between office intraocular pressure and 24-hour intraocular pressure in patients with primary open-angle glaucoma treated with a combination of topical antiglaucoma eye drops
Nakakura S; Nomura Y; Ataka S; Shiraki KJournal of Glaucoma 2007; 16: 201-204
PURPOSE: To determine the relation between office intraocular pressure (IOP) and 24-hour IOP in patients with primary open-angle glaucoma (POAG) treated with 3 kinds of antiglaucoma eye drops. PATIENTS AND METHODS: Subjects were 42 patients with POAG (71 eyes). All were being treated with 3 different topical antiglaucoma eye drops (latanoprost, [β]-blocker, and carbonic anhydrase inhibitor). Twenty-four-hour IOP values were obtained in the sitting position with a Goldmann applanation tonometer at 3-hour intervals. RESULTS: Maximum 24-hour IOP (mean±SD) was 19.76 ± 5.65 mmHg, minimum 24-hour IOP was 13.06 ± 4.75 mmHg, mean 24-hour IOP was 16.30 ± 4.90 mmHg, and 24-hour IOP fluctuation was 6.70 ± 2.81 mmHg. Office IOP was 16.23 ± 4.58 mmHg, and office IOP fluctuation was 2.75 ± 1.68 mmHg. There was no significant difference between office IOP and mean 24-hour IOP (P = 0.93). There was no correlation between office IOP and 24-hour IOP fluctuation (r = 0.15; P = 0.25) or between office IOP fluctuation and 24-hour IOP fluctuation (r = 0.19; P = 0.17). Maximum 24-hour IOP occurred during office hours in 22 eyes (33.8%). The frequency of maximum 24-hour IOP occurring during office hours was significantly less than that of minimum 24-hour IOP (P < 0.001). CONCLUSIONS: In POAG patients treated with 3 kinds of antiglaucoma eye drops, office IOP was similar to mean 24-hour IOP. However, it was difficult to estimate 24-hour IOP fluctuation and maximum 24-hour IOP on the basis of office IOP.
Dr. S. Nakakura, Department of Ophthalmology and Visual Sciences, Osaka City University, Graduate School of Medicine, Osaka 545-8585, Japan. s.nakakura@med.osaka-cu.ac.jp
Classification:
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)