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Abstract #16921 Published in IGR 9-1
Relationship of cerebral blood flow and central visual function in primary open-angle glaucoma
Harris A; Siesky B; Zarfati D; Haine CL; Catoira Y; Sines DT; McCranor L; Garzozi HJJournal of Glaucoma 2007; 16: 159-163
PURPOSE: To investigate the relations between middle cerebral artery (MCA) blood flow velocities and central visual function measured by foveal cone electroretinograms (ERG) and visual field. METHODS: Fifteen primary open-angle glaucoma patients were recruited. The eye with the more severe visual field defect (full threshold 24-2) and/or optic disc damage was chosen. Measurements included brachial arterial pressure, heart rate, visual acuity (logMAR), contrast sensitivity (CSV-1000), central visual field (Humphrey SITA 10-2), foveal cone ERG, and transcranial Doppler. Pearson correlation coefficients were estimated to assess the strength of the linear relationship between the MCA flow velocity and the other measured parameters. RESULTS: Visual field was successfully completed in 12 eyes. We were unable to obtain ERG responses and MCA velocity readings for 1 patient. A significant correlation was observed between MCA mean flow velocity and focal cone ERG amplitude [r = 0.69, n = 13, confidence interval (CI) 0.22, 0.90, P = 0.009], but correlation between mean foveal cone ERG implicit time and middle cerebral was not statistically significant (r = 0.011, n = 13, CI 0.47, 0.63). A significant correlation was also observed between MCA mean flow velocity and mean sensitivity (r = 0.76, n = 12, CI 0.32, 0.93, P = 0.005), and mean defect (r = 0.73, n = 12, CI 0.28, 0.92, P = 0.007) of the central visual field, logMAR visual acuity (r = 0.57, n = 14, CI 0.05, 0.84, P = 0.036), and contrast sensitivity (r = 0.61, n = 13, CI 0.09, 0.87, P = 0.027). CONCLUSIONS: Our findings suggest that in certain primary open-angle glaucoma patients diminished central visual function may be one manifestation of widespread cerebrovascular insufficiency.
Dr. A. Harris, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. alharris@indiana.edu
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
