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Abstract #17019 Published in IGR 9-1
Porcine model to compare real-time intraocular pressure during LASIK with a mechanical microkeratome and femtosecond laser
Hernandez-Verdejo JL; Teus MA; Roman JM; Bolivar GInvestigative Ophthalmology and Visual Science 2007; 48: 68-72
PURPOSE: To compare real-time intraocular pressure (IOP) during laser in situ keratomileusis (LASIK) in porcine eyes using two types of microkeratomes. METHODS: An interventional, prospective study of two microkeratomes: a Moria 2 (Moria group) and an IntraLase femtosecond laser (IntraLase Corp., Irvine, CA; IntraLase group). These devices were used to create lamellar corneal flaps in freshly enucleated porcine eyes. The IOP changes induced by the procedures were recorded with a reusable blood pressure transducer connected to the anterior chamber by direct cannulation. RESULTS: Seven porcine eyes were studied in each group. The IOP increased during the suctioning phase, reaching a mean of 122.52 ± 30.40 and 160.52 ± 22.73 mmHg during the cutting phase in the Moria group (the total time in this group was 36.42 ± 7.48 seconds; suctioning required 21.42 ± 7.48 seconds and the cutting phase, 15 ± 2.88 seconds). In the IntraLase group, the IOP reached 89.24 ± 24.26 mmHg during the suctioning phase and 119.33 ± 15.88 mmHg during the intrastromal laser application (the total time was 92.85 ± 13.49 seconds; suctioning required 40.00 ± 9.57 seconds and the cutting phase 52.85 ± 5.66 seconds). Both IOPs during both phases differed significantly between the two groups (P = 0.01 for all comparisons). CONCLUSIONS: Real-time IOP can be measured during LASIK using a transducer connected to the anterior chamber. The results showed a significant increase in IOP during the procedure in both groups, although with the IntraLase the IOP seemed to increase to a lesser extent than with the conventional mechanical microkeratome.
Dr. J.L. Hernandez-Verdejo, Vissum Hospital Oftalmologico, Madrid, Spain
Classification:
9.4.11.4 Glaucomas associated with corneal surgery (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
