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Abstract #17028 Published in IGR 9-1
Effect of 2% dorzolamide on retinal blood flow: A study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol
Costagliola C; Campa C; Parmeggiani F; Incorvaia C; Perri P; D'Angelo S; Lamberti G; Sebastiani ABritish Journal of Clinical Pharmacology 2007; 63: 376-379
AIM: To investigate whether dorzolamide modifies peripapillary retinal haemodynamics in juvenile primary open-angle glaucoma (JPOAG) patients treated with timolol. METHODS: In 40 JPOAG subjects, before and after dorzolamide coadministration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field and retinal flowmetry. RESULTS: Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction [1.75 mmHg, 95% confidence interval (CI) 1.23, 2.26; P < 0.05], OPP increase (5.09 mmHg, 95% CI 2.97, 7.20; P < 0.02) and retinal blood flow improvement (35.0 arbitrary units, 95% CI 12.20, 57.80; P < 0.03). BP, HR and visual field indices did not change. CONCLUSIONS: Dorzolamide, in association or in fixed combination with timolol, significantly improves retinal blood flow in JPOAG patients.
Dr. C. Costagliola. Sezione di Clinica Oculistica, Dipartimento di Discipline Medico-Chirurgiche Della Comunicazione e del Comportamento, Universita degli Studi di Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy. ciro.costagliola@unife.it
Classification:
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
