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Abstract #17033 Published in IGR 9-1
The role of cathepsins in ocular physiology and pathology
Im E; Kazlauskas AExperimental Eye Research 2007; 84: 383-388
Cathepsins are proteases that were originally identified in the lysosome, where they participate in house keeping tasks such as degradation of phagocytosed photoreceptors. More recently, cathepsins have been detected outside of the lysosome, and associated with numerous diseases (keratoconus, retinal detachment, age related macular degeneration, and glaucoma). The most likely mechanism by which cathepsins contribute to ocular pathologies is via degradation of the extracellular matrix, and/or regulation of angiogenesis.
Dr. A. Kazlauskas. Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA. ak@eri.harvard.edu
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
