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Abstract #17042 Published in IGR 9-1
Agonists and antagonists targeting the different α2-adrenoceptor subtypes
Gentili F; Pigini M; Piergentili A; Giannella MCurrent Topics in Medicinal Chemistry 2007; 7: 163-186
Chemical and biological strategies have provided evidence for α2 -receptor heterogeneity, to date classified in three different subtypes, α2A , α2B , and α2C . These are widely distributed throughout the body and mediate numerous effects; therefore, the potential therapeutic indications of agonists and antagonists are numerous. Nevertheless, the lack of subtype-selectivity of the well-known compounds represents a major limit for their use. SAR studies may help to design new and more selective drugs.
Dr. M. Giannella. Department of Chemical Sciences, University of Camerino, via S. Agostino 1, 62032 Camerino, Italy. mario.giannella@unicam.it
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)