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Abstract #17064 Published in IGR 9-1
Primary congenital glaucoma and agenesis of corpus callosum
Saygili O; Dai AINeurology Psychiatry and Brain Research 2006; 13: 221-224
Glaucomas are a heterogeneous group of eye disorders, characterized mostly by elevated intraocular pressure. Primary congenital glaucoma is the most common childhood glaucoma. Primary congenital glaucoma is an autosomal recessive disorder caused by developmental defects of the trabecular meshwork and the anterior chamber angle. Imaging technology such as optical coherence tomography and measurement of central corneal thickness may play an important role in the assessment of children with suspected or known glaucoma. In the this study, we have reviewed MRI findings of the brain in the newborn with primary congenital glaucoma, retrospectively. We focused on the signs and symptoms of clinical manifestations in patients with PCG who had abnormal corpus callosum formation as MR findings. We found 3 of the 17 patients had abnormal MRI findings consistent with agenesis of corpus callosum. Examination of the anterior segments of these patients revealed that 3 patients with agenesis of the corpus callosum had significantly decreased vacuoles adjacent to the wall of the Schlemm's canal compared to other infants with PCG and normal MR findings. Comparing the clinical findings among these patients with normal MRI, one infant with agenesis of the corpus callosum had abnormally pupillary enlargement. Another infant had corneal haze for a week who then had resolution of corneal cloudiness. There appears to be a relationship between primary congenital glaucoma and agenesis of corpus callosum. Although this study had few patients, further studies with larger patients are needed to confirm these results.
Dr. O. Saygili, Augenklinik, Rosenhöhe 27, 33647 Bielefeld, Germany. oguzsaygili@yahoo.com
Classification:
9.1.1 Congenital glaucoma, Buphthalmos (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
2.16 Chiasma and retrochiasmal central nervous system (Part of: 2 Anatomical structures in glaucoma)
