advertisement
Abstract #17065 Published in IGR 9-1
Possible relationship between delayed myelinization and primary congenital glaucoma
Dai AI; Saygili ONeurology Psychiatry and Brain Research 2006; 13: 201-204
Primary congenital glaucoma (PCG) appears in the first months of life. Isolated congenital glaucoma is characterized by malformations of the irido-corneal angle of the anterior chamber of the eye. The classic triad of manifestations includes epiphora, photophobia, and blepharospasm. In the present study, we reviewed MRI findings of the brain in the newborn with PCG, retrospectively. We noticed that 2 of 17 infants had abnormal brain MR findings suggestive of delayed myelinization in the white matter. Examination of the anterior segments of these patients revealed that these 2 patients had significant abnormal trabecular meshwork compared to other infants with PCG and normal MR findings. Comparing the clinical findings among these patients with normal MRI, 2 infants with delayed myelinization had abnormal appearance of optic nerve head / optic nerve excavation. Another clinical finding is marked increased corneal diameter. Significant abnormal cup/disc ratio (optic nerve excavation) and increased corneal diamteres in these 2 patients with delayed myelinization may suggest that intraocular pressure can be more striking and more severe, revealing close relationship with PCG and abnormal myelinization in the white matter. Further studies with more patients are needed to confirm these results.
Dr. O. Saygili. Augenklinik, Rosenhöhe 27, 33647 Bielefeld, Germany. oguzsaygili@yahoo.com
Classification:
9.1.1 Congenital glaucoma, Buphthalmos (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
2.16 Chiasma and retrochiasmal central nervous system (Part of: 2 Anatomical structures in glaucoma)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)