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Abstract #17078 Published in IGR 9-1
New perspectives in ocular pharmacology: Nucleotides as therapeutic agents
Pintor JAnales de la Real Academia Nacional de Farmacia 2006; 72: 519-538
Diadenosine polyphosphates are a group of nucleotides which modulate physiological processes in the eye such as tear secretion, corneal wound healing and intraocular pressure. This regulation is carried out by P2 purinergic receptors termed P2X and P2Y as well as dinucleotide receptors. Diadenosine polyphosphates are present in tears and when topically applied they can produce tear secretion in a process mediated by P2Y receptors. P2Y receptors are also present in corneal epithelial cells and they can accelerate the rate of re-epithelialization after superficial injuries. On the other hand, intraocular pressure is reduced by all those nucleotides activating P2X receptors. Due to the importance of the presence of these receptors in ocular structures it is possible to think in the use of dinucleotides, naturally occurring and synthetic ones, for the treatment of dry eye, corneal injuries and glaucoma.
Dr. J. Pintor, Dep. Bioquimica, E.U. Optica, Universidad Complutense de Madrid, C/ Arcos de Jalon, s/n, 28037, Madrid. jpintor@vet.ucm.es
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
