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Abstract #17086 Published in IGR 9-1
An open-label multicenter study on the efficacy and safety of topical use of latanoprost for 156 weeks
Kitazawa YJapanese Journal of Clinical Ophthalmology 2006; 60: 2047-2054
PURPOSE: To evaluate the efficacy and safety of topical application of latanoprost for 156 weeks. CASES AND METHOD: The present multicenter study was made on 158 cases, comprising 140 cases of primary open-angle or normal-tension glaucoma and 18 cases of ocular hypertension. The series comprised 81 males and 77 females. Their age ranged from 27 to 86 years, average 58 years. A final evaluation was made on 113 cases after eliminating disqualified cases. FINDINGS: The intraocular pressure (IOP) significantly decreased by an average of 3 mmHg (p < 0.01). The visual field remained unchanged during 3 years of treatment. Iris pigmentation increased by 41% with slit-lamp microscopy and by 1.9% without. CONCLUSION: Stable reduction of IOP was obtained by instillation of latanoprost for 3 years. The visual field remained stable in primary open-angle glaucoma and ocular hypertension. This therapeutic modality showed minimal adverse events including iris pigmentation.
Dr. Y. Kitazawa, Akasaka Kitazawa Ophthalmic Clinic, Akasaka Shuzan Bld., 5-5-13 Akasaka, Tokyo 107-0052, Japan.
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
