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Abstract #17139 Published in IGR 9-1
Long-term effects of isopropyl unoprostone monotherapy on intraocular pressure and visual field for normal-tension glaucoma and primary open-angle glaucoma patients
Saito Y; Saeki T; Sugiyama KNippon Ganka Gakkai Zasshi 2006; 110: 717-722
We retrospectively investigated the long-term effects of isopropyl unoprostone monotherapy on intraocular pressure and visual field for normal-tension glaucoma and primary open-angle glaucoma patients. Among 80 eyes of 49 subjects receiving isopropyl unoprostone monotherapy for 2 years or more, 32 eyes of 32 subjects were analyzed because of the good reliability of their visual acuity and visual field (age, 68.1 ± 10.1 yrs, follow-up period 47.8 ± 14.7 months). The mean values of intraocular pressure and visual field indices were compared with baseline data before medication. The visual field changes were also analyzed using the Kaplan-Meier life-table method. The mean intraocular pressure decreased for 4 years from 14.7 ± 4.3 mmHg (mean ± SD) at baseline, to 12.7 ± 4.4 mmHg at 4 years. The global index of visual field (mean defect, loss variance) did not change significantly during the 4 years. The accumulative probability of survival was 80.7 ± 8.0% after 4 years when the endpoint was defined as 3dB progression in mean defect. Isopropyl unoprostone might have the possibility of stabilizing the visual field for a long period of time. LA: Japanese
Dr. Y. Saito, Department of Opthalmology, Kanazawa University School of Medicine, Japan. saito-yo@med.kanazawa-u.ac.jp
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
