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Abstract #17476 Published in IGR 9-2
Clinical analysis of corticosteroid-induced ocular hypertension after laser keratorefractive surgery
Wang X-Q; Zhai J-Y; He X-G; Bai JInternational Journal of Ophthalmology 2007; 7: 429-431
AIM: To study the incidence, clinical related factors and therapeutic effects of corticosteroid-induced ocular hypertension after laser keratorefractive surgery (LASIK and LASEK). METHODS: A follow-up study on four 060 eyes after laser keratorefractive surgery between December 2005 and December 2006 was performed. Corticosteroid (1g/L dexamethasone and 1g/L fluoromethalone) eye drops were applied 2-3 months post-operatively and intraocular pressure was measured at 1 week, 1, 2, 3, 6 and 12 months, the eyes with increase of intraocular pressure were treated. Binary logistic regression was used to analyze the relationship between ocular hypertension and age, sex, eye, maximum diopter, maximum curvature, cornea cutting depth, and vertical cup/disc ratio. RESULTS: Corticosteroid-induced ocular hypertension occurred in 3.5% of the four 060 eyes. The intraocular pressure (IOP) of the eyes dropped to normal level in all patients after drug treatments. Results of binary logistic regression showed significance (P value) between ocular hypertension and cup/disc ratio was 0.015 and all others exceeded 0.1, OR ratio: 3.071, which mean that incidence of corticosteroid-induced ocular hypertension on patients with vertical cup/disc ratio exceeding 0.4 was more than three times than those with cup/disc ratio less than 0.4. CONCLUSION: Topical application of corticosteroid drops may cause corticosteroid-induced hypertension in somebody after laser keratorefractive surgery. There is close correlation between corticosteroid-induced hypertension and vertical cup/disc ratio. Cup/ disc ratio exceeding 0.4 is a risk factor to corticosteroid-induced ocular hypertension. To those with cup/disc ratio exceeding 0.4, we can reduce corticosteroid dosage and/or use drugs to lower IOP. LA: Chinese
Dr. X.-G. He, Department of Opthalmology, Institute of Field Surgery, The Military Medical University, Chongqing 400042, China. xiangge_he@hotmail.com
Classification:
9.4.1 Steroid-induced glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
8.4 Refractive surgical procedures (Part of: 8 Refractive errors in relation to glaucoma)
