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Abstract #17500 Published in IGR 9-2
Central corneal thickness in pediatric glaucoma
Lopes JF; Wilson RP; Alvim HS; Shields CL; Shields JA; Calhoun J; Fontanarosa J; Steinmann WCJournal of Pediatric Ophthalmology & Strabismus 2007; 44: 112-117
PURPOSE: To compare the central corneal thickness (CCT) of children with and without glaucoma and to estimate the effect CCT may have on the intraocular pressure (IOP) assessment of children. Patients and METHODS: CCT and IOP measurements were performed in an unmasked fashion in 34 consecutive children with glaucoma and 28 consecutive children without glaucoma. Patients with corneal edema or extensive corneal scarring were excluded. IOPs in the pediatric glaucoma group were corrected for CCT using a linear algorithm; adjustments of 3 mmHg or more were considered clinically significant. RESULTS: Mean CCT for eyes with glaucoma was 610.2 ± 121.9 μm; for the control eyes, mean CCT was 555.6 (±) 38.4 μm (P < .001). Mean CCT was 543.3 ± 66.9 μm for eyes with primary congenital glaucoma, 591.9 ± 23.1 μm for those with Sturge-Weber syndrome, 662.7 ± 68.7 μm for those with aphakic glaucoma, 754.5 ± 92.6 μm for those with aniridia, and 820.6 ± 133.7 μm for those with microcornea (P < .001). Applying a correction formula for IOP with CCT adjustment, the adjusted IOP was overestimated by ≥ 3 mmHg in 14 (41.2%) eyes and underestimated by ≥ 3 mmHg in 5 (14.7%) eyes. CONCLUSIONS: The mean CCT was higher for the pediatric glaucoma group than for the control group. However, the CCTs varied significantly depending on the specific diagnoses. CCT was estimated to have a clinically significant effect on IOP measurements in more than half of the patients with pediatric glaucoma. Pachymetry results should be considered in the management of these patients.
Dr. R.P. Wilson, Glaucoma Service, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA
Classification:
9.1 Developmental glaucomas (Part of: 9 Clinical forms of glaucomas)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)