advertisement
Abstract #17509 Published in IGR 9-2
Failure of intracameral fluorouracil to resolve an epithelial ingrowth following clear corneal cataract surgery
Tomlins PJ; Savant V; Quinlan MJournal of Cataract and Refractive Surgery 2007; 33: 923-924
We present a case of epithelial ingrowth that progressed despite repeated intracameral injections of fluorouracil (5-FU). Six months after cataract surgery, a retrocorneal membrane was found advancing from the corneal section. At 1 year, 0.5 mg of 5-FU in 0.1 mL of balanced salt solution was exchanged for 0.1 mL of aqueous. Ingrowth initially stopped, but progressed 6 months later. Two further injections of 0.5 mg of 5-FU were given at 1-month intervals, followed by 1 mg of 5-FU 3 and 6 months later. Each injection initially halted progression of the ingrowth, but then it recurred. Ultimately, the treatment failed to prevent progression of the disease and angle-closure glaucoma ensued. Resolution of epithelial ingrowth with intracameral 5-FU has been reported twice. We found no reports of such treatment following clear corneal cataract surgery or with eventual epithelial ingrowth progression. Epithelial ingrowth remains a relentless and challenging condition to treat.
Dr. P.J. Tomlins, Ophthalmology Department, Sandwell General Hospital, Lyndon, West Bromwich, West Midlands, UK. paultomlins@mac.com
Classification:
9.4.11.3 Epithelial, fibrous, and endothelial proliferation (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
