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Abstract #17958 Published in IGR 9-2
Experimental study a new device of scleral flap stent on filtration surgery in normal sheep
Zhang XX; He ZJ; Yan YM; Lin JY; Xu S; Gao JM; Xu YH; Yan HChinese Journal of Ophthalmology 2007; 43: 129-133
OBJECTIVE: To test the effectiveness and safety of a filtering drainage device, a scleral flap stent (SFS) made of poly methyl methacrylate (PMMA) in trabeculectomy (or filtering drainage-plasty) in sheep. METHODS: Thirty-two normal sheep were used. Trabeculectomy was performed in both eyes and the filtering drainage device, a SFS was randomly implanted under the scleral flap in one eye. After the surgery, the intraocular pressure (IOP) was measured by Schiotz tonometer; The filtering blebs and its histopathology was examined by a slit lamp, an ultrasound biomicroscope (UBM), and electromicroscope. RESULTS: The IOP in eyes with trabeculectomy plus SFS was statistically significantly (P < 0.001) lower than that in eyes with trabeculectomy along at one month (11.38 ± 1.20) mmHg vs (14.05 ± 0.93) mmHg and at three months (11.95 ± 1.18) mmHg vs (15.2 ± 1.09 mmHg). Compared to the pre-operation, no difference in IOP was found at one month in eyes with trabeculectomy along (16.04 ± 1.02) mmHg vs (14.05 ± 0.93) mmHg. The filtering bleb was lasted more than 3 months in eyes with trabeculectomy plus SFS while existed only one month in eyes with trabeculectomy along by both slit lamp and UBM examination. The fibroblastic proliferation of filtering pathway and scar formation was found at one months post-operation in eyes with trabeculectomy along, however, the fibroblastic proliferation and the scar formation were found at three months and at six months after surgery in eyes with trabeculectomy plus SFS, respectively, by a light and electromicroscopy examination. Tissue compliance was good and no elimination occurred. No toxic or adverse effects were observed in the following year post-operatively. CONCLUSION: SFS is a safe and effective newly designed filtering drainage device in lowering IOP when performed together with trabeculectomy. LA: Chinese
Dr. X.X. Zhang, Department of Ophthalmology, The Tianjin Medical University General Hospital, Tianjin 300052, China. zhang_xuxiang@hotmail.com
Classification:
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
