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Abstract #18050 Published in IGR 9-2
Effect of bimatoprost on intraocular pressure after phacoemulsification in eyes with exfoliation syndrome
Takmaz T; Can I; Gürdal C; Kürkçüoğlu P; Aşik SActa Ophthalmologica Scandinavica 2007; 85: 262-266
PURPOSE: To evaluate the effect of bimatoprost 0.03% on intraocular pressure (IOP) after phacoemulsification in eyes with exfoliation syndrome. METHODS: This prospective, randomized, masked study comprised 90 eyes of 90 patients scheduled for phacoemulsification. The patients were divided into three groups (group 1 = without exfoliation, group 2 = with exfoliation syndrome, group 3 = exfoliation syndrome + bimatoprost). Immediately after phacoemulsification, one drop of bimatoprost was instilled in eyes in group 3. Baseline IOP was measured 1 day before surgery and routine follow-ups were performed at 6 hours, 20-24 hours and 1 week postoperatively. RESULTS: Preoperative IOP was 15.0 ± 2.7 mmHg in group 1, 15.6 ± 3.2 mmHg in group 2 and 16.1 ± 3.2 mmHg in group 3 (p = 0.372). Six hours postoperatively, there was a significant difference between the groups (p = 0.013): IOP in group 2 (22.4 ± 7.3 mmHg) was higher than in group 1 (18.4 ± 4.4 mmHg) (p = 0.018) and group 3 (18.9 ± 4.9 mmHg) (p = 0.044). In all groups, IOP values at 6 hours postoperatively were higher than preoperative values (p < 0.001), but IOP values at 20-24 hours and 1 week after surgery were not significantly different from baseline values (p > 0.05). The change in IOP in group 2, from baseline to 6 hours postoperatively, was greater than the equivalent changes in group 1 (p = 0.048) and group 3 (p = 0.016). CONCLUSIONS: Transient IOP increase and spikes were more common in eyes with exfoliation syndrome. Postoperative application of bimatoprost was effective in reducing IOP and preventing IOP spikes ≥ 30 mmHg in eyes with exfoliation syndrome in the early postoperative period.
Dr. T. Takmaz, Second Ophthalmology Department, Atatürk Training and Research Hospital, Ankara, Turkey. takmaz@isbank.net.tr
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
11.4 Prostaglandins (Part of: 11 Medical treatment)