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Abstract #18109 Published in IGR 9-2
Natural course of intraocular pressure after cataract surgery with sodium hyaluronate 1% versus hydroxypropylmethylcellulose 2%
Rainer G; Schmid KE; Findl O; Sacu S; Kiss B; Heinzl H; Menapace ROphthalmology 2007; 114: 1089-1093
PURPOSE: To investigate the natural course of intraocular pressure (IOP) after small-incision cataract surgery with sodium hyaluronate 1% versus hydroxypropylmethylcellulose 2%. DESIGN: Randomized clinical trial. PARTICIPANTS: Eighty eyes of 40 consecutive patients with bilateral age-related cataract. METHODS: The patients were assigned randomly to receive sodium hyaluronate 1% or hydroxypropylmethylcellulose 2% during cataract surgery in the first eye. The second eye received the other ophthalmic viscosurgical device. The IOP was measured preoperatively and 30 minutes; 1, 2, 3, 4, 6, 8, and 20 to 24 hours; and 1 week postoperatively. MAIN OUTCOME MEASURE: Postoperative IOP increase. RESULTS: The highest mean IOP increase occurred at 8 hours postoperatively (5.3 ± 6.4 mmHg) in the sodium hyaluronate 1% group and at 2 hours postoperatively (7.8 ± 6.1 mmHg) in the hydroxypropylmethylcellulose 2% group. Overall, the IOP increase was higher with hydroxypropylmethylcellulose 2% (P = 0.005). Intraocular pressure spikes to ≥ 30 mmHg occurred in 5 eyes (13%) in the sodium hyaluronate 1% group and 13 eyes (33%) in the hydroxypropylmethylcellulose 2% group. CONCLUSIONS: Sodium hyaluronate 1% and hydroxypropylmethylcellulose 2% caused significant IOP increases during the first 8 hours after cataract surgery. A single measurement at 6 hours postoperatively could detect all IOP spikes in the sodium hyaluronate 1% group. In the hydroxypropylmethylcellulose 2% group, a single measurement at 2 hours postoperatively could detect two thirds of IOP spikes.
Dr. G. Rainer, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Georg.rainer@meduniwien.ac.at
Classification:
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
13.2.1 IOP (Part of: 13 Therapeutic prognosis and outcome > 13.2 Outcome)
