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1 General aspects (0)   1.1 Epidemiology (9)   1.2 Population genetics (3)   1.3 Pathogenesis (0)   1.4 Quality of life (3)   1.5 Glaucomas as cause of blindness (6)   1.6 Prevention and screening (4) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (0)   2.2 Cornea (19)   2.3 Sclera (2)   2.4 Anterior chamber angle (2)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (7)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (0)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (3)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (1)   2.9 Ciliary body (4)   2.10 Lens (1)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (4)   2.13 Retina and retinal nerve fibre layer (24)   2.14 Optic disc (17)   2.15 Optic nerve (4)   2.16 Chiasma and retrochiasmal central nervous system (1)   2.17 Stem cells (2)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (5)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (5)     3.4.2 Gene studies (19)   3.5 Molecular biology incl. 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Miscellaneous (5)

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Abstract #18158 Published in IGR 9-2

Experimental studies on the existence and distribution characteristics of neural stem cells in adult human ciliary body and retina

Hu L; Tang S-B; Ma L; Wu L-L; Shen H-X
Chinese Journal of Ophthalmology 2007; 43: 222-227

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OBJECTIVE: To investigate the existence and distribution characteristics of neural stem cells in the eyes of adult human ciliary body and retina. METHODS: Eight eyes from 20-40 years old health adult and 3 infant eyes were obtained from Guangdong Eye Bank and were used in the present studies. The protein and mRNA expressions of neural progenitor cell-specific antigen nestin in the ciliary body and retina were detected by immunohistochemical staining and reverse RT -PCR assays, respectively. The ultrastructural and distribution characteristics of these cells were studied by transmission electron microscopy (TEM). RESULTS: Immunohistochemical staining showed that there were a few nestin-positive cells existed in pigment epithelium layer of ciliary body and inner nuclear layer (1NL) of retina. mRNA expression of nestin gene was detected in both the ciliary body and retina of the infant and adult eyes by RT -PCR assays. The expression of nestin in the infant ciliary body was higher than that of the adult eye. By TEM, a few cells with the characteristic morphology of neural stem cells were identified and their location was consistent with the results of immunohistochemical staining. CONCLUSION: Cells with the features of neural stem cells are present in the pigment epithelium layer of ciliary body and the inner nuclear layer of retina in adult human eyes. LA: Chinese

Dr. S-B Tang, Zhongshan Ophthalmic Cenrer, SUN Yat-sen University, Guangzhou 510060, China.tangsb@mail. Sysu.edu.cn

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Classification:

2.17 Stem cells (Part of: 2 Anatomical structures in glaucoma)
2.9 Ciliary body (Part of: 2 Anatomical structures in glaucoma)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
3.3 Immunohistochemistry (Part of: 3 Laboratory methods)

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