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Abstract #18196 Published in IGR 9-2
Vascular risk factors in glaucoma: the results of a national survey
Orzalesi N; Rossetti L; Omboni S; OPTIME Study GroupGraefe's Archive for Clinical and Experimental Ophthalmology 2007; 245: 795-802
BACKGROUND: The role of vascular risk factors in glaucoma is still being debated. To assess the importance of vascular risk factors in patients with primary open-angle glaucoma (POAG), data from the medical history of 2,879 POAG patients and 973 age-matched controls were collected and analyzed. DESIGN: Observational survey. SETTING: Thirty-five Italian academic centers. Study population: POAG patients and age-matched controls. In order to reduce bias consecutive patients were included. Observation procedures: data concerning vascular risk factors were collected for all patients with a detailed questionnaire. A complete ophthalmological examination with assessment of intraocular pressure (IOP), visual field, optic disc, and systemic blood pressure was performed. MAIN OUTCOME MEASURES: the ESH-ESC (European Society of Hypertension-European Society of Cardiology) guidelines were used to calculate the level of cardiovascular risk. Crude and adjusted estimates of the odds ratios (OR) were calculated for all cardiovascular risk factors in POAG and controls. RESULTS: The study included 2,879 POAG patients and 973 controls. POAG cases had a significantly higher systolic and diastolic blood pressure (p = 0.001) and systolic perfusion pressure (p = 0.02) as compared with controls. Also mean IOP was significantly higher in the POAG group (p = 0.01), while diastolic perfusion pressure was not significantly different in the two groups. Myopia was more prevalent in the POAG group (23 vs 18%, p = 0.005) as well as a positive family history for glaucoma (26 vs 12%, p = 0.004). POAG patients tended to have a higher cardiovascular risk than controls: 63% of glaucoma cases vs 55% of controls (OR: 1.38, p = 0.005) had a 'high' or 'very high' cardiovascular risk. CONCLUSIONS: The level of cardiovascular risk was significantly higher in glaucoma patients than in controls.
Dr. N. Orzalesi, Osservatorio sulla Patologia glaucomatosa, Indagine Medico Epidemiologica, CONPROSO, Department of Medicine, Surgery and Odontology, University of Milan, San Paolo Hospital, Milan, Italy, nicola.orzalesi@unimi.it
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
