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Abstract #18285 Published in IGR 3-3
Trabeculectomy with and without mitomycin-C in a black African population
Mwanza JCK; Kabasele PMEuropean Journal of Ophthalmology 2001; 11: 261-263
PURPOSE: To evaluate the beneficial effects of intraoperative application of mitomycin C during trabeculectomy in a black African population in Congo-Kinshasa. METHODS: A prospective randomized study in 22 eyes (11 patients) with open-angle glaucoma. All patients underwent trabeculectomy with the application of mitomycin C (0.4 mg/ml for 2.5 minutes) under the scleral flap in the right eye, and trabeculectomy alone in the left eye. Assessment of the clinical outcome included intraocular pressure (IOP), visual acuity, visual field, and complications. The follow-up was 20 months. Success of the filtering surgery was defined as a final IOP of 21 mmHg or lower without antiglaucoma medications and no further glaucoma surgery necessary. RESULTS: The success rate of trabeculectomy was 81.8% in eyes treated with mitomycin C compared with 63.6% in eyes not receiving this drug. Rates of IOP reduction were 57.9% and 42.9%, respectively. Complications occurred in 36.3% of the eyes managed with mitomycin C compared with 9% in the control eyes. CONCLUSIONS: Mitomycin C, as adjunctive treatment during trabeculectomy in black Africans, offers great benefit in lowering IOP, but has a substantial high risk of complications. These data need to be confirmed by further studies in this population.
Dr J.-C.K. Mwanza, University of Bergen, Centre for International Health, Haukeland University Hospital, N-5021 Bergen, Norway. jcmwanza@hotmail.com
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)