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Abstract #18316 Published in IGR 3-3
Endothelin-1 increase in aqueous humour caused by frequency-doubled Nd:YAG laser trabeculoplasty in rabbits
Guzey M; Vural H; Satici AEye 2001; 15: 781-785
PURPOSE: To study the effect of Nd:YAG laser trabeculoplasty (LT) on endothelin-1 (ET-1) concentration of aqueous humor and intraocular pressure (IOP) in rabbits. METHODS: One eye of each of 18 pigmented rabbits was subjected to 360° LT with a frequency-doubled Nd:YAG laser (532 nm), and IOP was measured with a Tono-Pen tonometer before treatment. Post-LT, IOP measurements followed by aqueous humor aspiration were performed under general anesthesia at three and 12 hours and one, three, and seven days after the treatment. The concentration of ET-1 in the aqueous humor was measured by means of a radioimmunoassay. RESULTS: In the eyes that had undergone LT, the concentrations of ET-1 in the aqueous humor were significantly increased at three, 12, and 24 hours after the treatment compared with the contralateral eyes. However, ET-1 concentrations at three and seven days after LT did not differ significantly from the corresponding contralateral control values. IOP increased following the treatment at three and 12 hours. IOP values were significantly lower in the treated eyes at one, three, and seven days after treatment than in the control eyes. CONCLUSIONS: The results show that LT in rabbits was followed by an immediate and short-term increase in aqueous humor ET-1 that might be caused by leakage from uveal tissue. This may be responsible for the release of prostaglandins causing the IOP increase and inflammatory complications of LT.
Dr M. Guzey, Forsa Sok. Guney Ap. No 21, Daire 1, Senesenevler Bostanci, Istanbul, Turkey. guzey@turk.net
Classification:
12.2 Laser iridotomy (Part of: 12 Surgical treatment)
