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Abstract #18322 Published in IGR 3-3
The pH of the rabbit's aqueous humor response on antiglaucomatics
Veselovsky J; Olah Z; Vesela A; Gressnerova SČeska a Slovenska Oftalmologie 2001; 57: 219-225
In this contribution, the activity of antiglaucomatics: 2% pilocarpine (pH 5.98), 0.5% timoptol (pH 6.58). and 0.005% xalatan (pH 6.83), is emphasized from the point of view of pH values and changes of the pH values of the rabbit aqueous humor in vitro after their application. The rabbit's aqueous humor pH is 7.59: similar to that in human healthy eyes (7.5-7.6). The authors observed that these antiglaucomatics decrease the aqueous humor pH to the acid levels in the following order: 2% pilocarpine > 0.5% timoptol > 0.005% xalatan. The most significant decrease was measured immediately after the application. From the point of view of speed of response and effectiveness in time achieving pH of normal aqueous humor, the authors we suggest the following order: 0.005% xalatan > 0.5% timoptol > 2% pilocarpine. The changes in pH of the aqueous humor after application of these antiglaucomatics are directly connected to their physiological function in the eye. Moreover, they also point out the importance of the pH dependence of antiglaucomatics applied into the conjunctival sac in the treatment of glaucomatous disease. LA: Slovak
Dr J. Veselovsky, Katedra Zivocis. Fyziol. a Etol., Prirodovedecka Fakulta, Univerzita Komenskeho, Mlyanska dolina B-2, 842 15 Bratislava, Slovakia
Classification:
11.20 Other (Part of: 11 Medical treatment)
