advertisement
Abstract #18327 Published in IGR 3-3
Effect of ketanserin administration on intraocular pressure
Tekat D; Güler C; Kemal Arici M; Topalkara A; Erdöl HOphthalmologica 2001; 215: 419-423
PURPOSE: The authors evaluated the effect of oral single-dose (20 mg) ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes. METHODS: This study included 15 healthy volunteers and 16 patients with ocular hypertension. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, IOP, and pupil diameter were recorded at baseline and at one-hourly intervals for six hours; in addition, tonographic outflow facility was studied at the third hour after the administration of placebo or an oral single dose of 20-mg ketanserin, given in a randomized, double-blind, crossover fashion. The alternative treatment was applied a week later. RESULTS: In both groups, oral single-dose (20 mg) ketanserin significantly lowered IOP and SBP (p < 0.01). No variation was observed in DBP, heart rate, or pupil diameter (p > 0.01). Moreover, after drug administration, the total outflow facility measured by conventional tonography increased in a statistically significant way (p < 0.01). Placebo did not induce any significant reduction in IOP or SBP in either group. CONCLUSION: The results showed that systemic ketanserin can be used in the treatment of glaucoma patients to reduce IOP.
Dr D. Tekat, Department of Ophthalmology, School of Medicine, Cumhuriyet University, Sivas, Turkey
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
