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Abstract #18351 Published in IGR 3-3
Topical latanoprost and optic nerve head and retinal circulation in humans
Tamaki Y; Nagahara M; Araie M; Tomita K; Sandoh S; Tomidokoro AJournal of Ocular Pharmacology and Therapeutics 2001; 17: 403-411
The purpose of the present study was to study the effect of a single instillation of latanoprost on the human optic nerve head (ONH) and retinal circulation. Using laser-speckle tissue blood flow analysis, normalized blur (NB; a quantitative index of tissue blood velocity) was measured every 0.125 seconds at a temporal ONH site free of visible surface vessels. Measurements were averaged for three cardiac cycles (NBONH). Color Doppler imaging (CDI) was also used to evaluate peak systolic blood velocity (PSV), endodiastolic velocity (EDV), and resistive index (RI) in the central retinal artery (CRA) and mean blood velocity (MV) in the central retinal vein (CRV). One drop of 0.005% latanoprost was instilled into one eye and its vehicle into the other in 11 healthy volunteers, in a double-blind manner. Measurements of bilateral NBONH, CDI parameters, intraocular pressure (IOP), blood pressure (BP), and pulse rate (PR) were performed before, and 45, 90, 180, and 270 minutes after instillation. After a single instillation of latanoprost or the vehicle, there was no significant bilateral difference throughout the experimental period. The difference in NBONH between that before and at each time point of measurement (δNBONH in the latanoprost-treated eyes was significantly higher between 45 and 270 minUTES after instillation than that in vehicle-treated eyes (P = 0.0003-0.0156); ANOVA for repeated measurements also revealed significant difference between both eyes (P < 0.00001). BP, PR, and NBONH in the eye that received only the vehicle, PSV, EDV, and RI in the CRA in both eyes, and MV in the CRV in both eyes changed little. Tissue blood velocity in the ONH increased at least temporarily following a single instillation of topical latanoprost. Although the mechanism of the increase is unclear, the effects of latanoprost on ONH tissue circulation in humans may have clinical implications.
Dr Y. Tamaki, Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. tamaki-tky@umin.ac.jp
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
