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Abstract #18352 Published in IGR 3-3
Effects of latanoprost and unoprostone when used alone or in combination for open-angle glaucoma
Saito M; Takano R; Shirato SAmerican Journal of Ophthalmology 2001; 132: 485-489
PURPOSE: To evaluate the effects of latanoprost and unoprostone on the intraocular pressure (IOP) and tonographic outflow facility in glaucoma patients, when used alone or in combination. DESIGN: Open-label randomized clinical study. METHODS: Fifty-two patients (52 eyes) with primary open-angle glaucoma were randomly divided into two groups. One group initially received only latanoprost 0.005% once daily and the other unoprostone 0.12% only, twice daily. The study period was 12 weeks: in the first six weeks, latanoprost or unoprostone was given as monotherapy, and in the last six weeks, patients received both drugs. IOP was measured every two weeks by one investigator masked to the medication received by patients during the study period in the same hour as on the baseline day. At weeks 0, 6, and 12, the coefficient of aqueous outflow was measured by tonography. RESULTS: With latanoprost monotherapy, the baseline IOP of 22.9 ± 2.4 mmHg (mean ± SD) decreased to 16.9 ± 2.1 mmHg (p < 0.01). When unoprostone was added to latanoprost, the IOP remained at 16.7 ± 2.5 mmHg. With unoprostone monotherapy, the baseline IOP of 22.7 ± 2.1 mmHg decreased to 19.4 ± 2.4 mmHg (p microm 0.01). When latanoprost was added to unoprostone, the IOP decreased to 16.8 ± 1.7 mmHg (p < 0.01). There was no significant change in the coefficient of aqueous outflow with monotherapy or the combined use of the drugs. CONCLUSION: The combination of latanoprost and unoprostone does not result in a more potent hypotensive effect than latanoprost alone.
Dr M. Saito, Department of Ophthalmology, Tokyo Medical University, Hachioji Medical Center, 1163 Tatemachi Hachioji, Tokyo, 193-0998, Japan. nmsaito@d8.dion.ne.jp
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
