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Abstract #18358 Published in IGR 3-3
Predictive value of a one-day, one-eye trial on the one-month ocular hypotensive response of latanoprost 0.005%
Mansberger SL; Passo MS; Schalock PI; Cioffi GAAmerican Journal of Ophthalmology 2001; 132: 869-871
PURPOSE: To determine whether a one-day, one-eye trial of latanoprost 0.005% was predictive of the one-month intraocular pressure (IOP) response in patients with uncontrolled open-angle glaucoma (OAP) on maximally tolerated medical therapy without latanoprost. METHODS: One eye each of 39 consecutive patients was enroled in a prospective trial of latanoprost 0.005%. An investigator, masked to treatment eye and IOP result, measured IOP at one day and one month after treatment. The diagnostic precision of the one-day, one-eye trial for the one-month result was determined at a 10, 20, and 30% reduction from baseline IOP. RESULTS: Treatment produced a mean ± SD (range) decreased in IOP of from 20.9 ± 4.6 (14-35) to 16.6 ± 3.6 (9-26) mmHg at 24 hours (p < 0.0001, paired t test). This reduction in IOP was similar at one month with mean ± SD (range) IOP of 16.1 ± 3.1 (9-22) mmHg (p < 0.0001, paired t test). The accuracy of the one-day, one-eye trial for the one-month response at a 10, 20, and 30% reduction of IOP from baseline IOP was 96% (Χ2 = 29.5, p < 0.001), 74% (Χ2 = 8.4, p = 0.004), and 80% (Χ2 = 10.2, p = 0.001), respectively. CONCLUSION: A one-day, one-eye trial of latanoprost 0.005% is predictive of the one-month IOP response in patients with uncontrolled OAG.
Dr S.L. Mansberger, Devers Eye Institute/Discoveries in Sight, 1040 NW 22nd Avenue, Suite 200, Portland, OR, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
