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Abstract #18359 Published in IGR 3-3
Intraocular pressure over 24 hours after single-dose administration of latanoprost 0.005% in healthy volunteers: a randomized, double-masked, placebo controlled, cross-over single center study
Larsson LIActa Ophthalmologica Scandinavica 2001; 79: 567-571
PURPOSE: To measure the effect on intraocular pressure (IOP) over 24 hours after single-dose administration of latanoprost 0.005%. PATIENTS AND METHODS: A randomized, double-masked, placebo-controlled, cross-over study was carried out. Twenty healthy volunteers were randomly assigned to receive a single drop of latanoprost 0.005% or placebo, with a two-week washout period before switching therapy. After hospitalization, the IOP was measured repeatedly over 24 hours, and again after 36 and 48 hours. RESULTS: The maximum IOP reduction for latanoprost occurred 12 hours after the dose, with IOP 11.7 ± 0.5 mmHg (least square mean ± standard error of the mean (SEM)) for latanoprost and 13.5 ± 0.5 mmHg for placebo. The difference of 1.8 ± 0.6 mmHg was statistically significant in favor of latanoprost (p = 0.01; ANOVA, confidence interval (CI -3.1; -0.5 mmHg). The average time to onset of action, defined as 50% of the maximum IOP reduction, was 6.0 hours for latanoprost. Latanoprost consistently reduced IOP over 24 hours after drop application, with a difference in IOP reduction of 1.1 ± 0.5 mmHg (p = 0.03; CI -2.1, 0.1) at 24 hours. The corresponding IOP difference at 36 hours was 0.7 ± 0.5 mmHg (p = 0.20; CI -1.7, 0.3), and at 48 hours 0.8 ± 0.5 mmHg (p = 0.04; CI -1.5, 0.0). CONCLUSIONS: Latanoprost applied as a single dose reduced IOP over 24 hours in healthy subjects compared with placebo. The IOP reduction was still present, however, less pronounced, 48 hours after drug application.
Dr L.I. Larsson, Department of Ophthalmology, Uppsala University Hospital, Uppsala, Sweden
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)