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Abstract #18362 Published in IGR 3-3
Liposomal prostaglandin E1 enhances optic nerve head blood flow in cats
Kitanishi K; Harino S; Suzuki M; Okamoto N; Reinach PJournal of Ocular Pharmacology and Therapeutics 2001; 17: 115-122
The authors investigated the effects of the intravenous administration of prostaglandin E1 (PGE1) and lipo-prostaglandin E1 (lipo-PGE1), on optic nerve head blood flow (ONHBF) of ten anesthetized cats. Changes in relative ONHBF were noninvasively and continuously measured with fundus camera-based laser Doppler flowmetry. The blood pressure (BP) decreased significantly by 6 ± 5 (mean ± SD)% and 8 ± 4%, respectively, after PGE1 (30, 100 ng/kg/min) administration, but at either of these concentrations there were no significant changes in ONHBF. On the other hand, with lipo-PGE1 (10 ng/kg/min), the BP remained unchanged, but ONHBF increased significantly by 61 ± 49%. A larger dose of lipo-PGE1 (30 ng/kg/min) had the opposite effect because the BP decreased significantly by 14 ± 4% after administration, and the ONHBF remained unchanged (i.e., 67 ± 102%). In no case was there a change in IOP. With 10 ng lipo-PGE1, the large increase in ONHBF can be accounted for by vasodilation, since the perfusion pressure was unchanged. The inability of 30 ng lipo-PGE1 to affect ONHBF could be ascribed to the decrease in BP resulting in decreased ocular circulation. These results suggest that, in humans, lipo-PGE1 may also increase ONHBF provided that it is used at doses that do not produce large decreases in BP.
Dr K. Kitanishi, Department of Ophthalmology, Izumiotsu Municipal Hospital, Osaka, Japan. kunikok@ya2.so-net.ne-jp
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)