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Abstract #18366 Published in IGR 3-3
Comparison of topical travoprost eye drops given once daily and timolol 0.5% given twice daily in patients with open-angle glaucoma or ocular hypertension
Goldberg I; Cunha-Vaz J; Jakobsen JE; Nordmann JP; Trost E; Sullivan EK; International Travoprost Study ; GroupJournal of Glaucoma 2001; 10: 414-422
PURPOSE: This nine-month study compared the intraocular pressure (IOP)-lowering efficacy and safety of one-daily travoprost ophthalmic solutions (0.0015% and 0.004%) with twice-daily timolol 0.5%. PATIENTS AND METHODS: This study was conducted using a double-masked, randomized, parallel-group design; adult patients with open-angle glaucoma or ocular hypertension (IOP between 24 and 36 mmHg, inclusive, at 9 a.m. and between 21 and 36 mmHg, inclusive, at 11 a.m. and 4 p.m. on two eligibility visits after an appropriate washout of previous treatments). In both eyes, the travoprost vehicle (placebo) was instilled at 9 a.m. and travoprost (0.0015% or 0.004%) at 9 p.m., or timolol 0.5% at both times. The primary efficacy variable was mean IOP measured at 9 a.m., 11 a.m., and 4 p.m. at baseline and follow-up visits. RESULTS: Five hundred and seventy-three patients were randomized to the study treatments. Mean IOP, which was combined across study visits, was lower with traboprost 0.004% than with timolol 0.5% at 9 a.m. (p = 0.0246), 11 a.m. (p = 0.0039), and 4 p.m. (p = 0.0004). IOP was lower with travoprost 0.004% than with travoprost 0.0015% at 11 a.m. (p = 0.0314), the time of peak drug activity. Mean IOP was consistently lower with travoprost 0.0015% than with timolol 0.5%. Mean IOP reductions from baseline were significantly (p
Dr I. Goldberg, Floor 4, 187 Macquarie Street, Sydney NSW 2000, Australia
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
