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Abstract #18367 Published in IGR 3-3
Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients
Chiba T; Kashiwagi K; Kogure S; Abe K; Shibuya T; Furuichi M; Iijima H; Tsukahara SJournal of Glaucoma 2001; 10: 406-410
PURPOSE: To investigate the incidence of iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients by a prospective and observer-masked study. PATIENTS AND METHODS: sixty-nine eyes of 69 glaucoma patients were included. Patients who had undergone intraocular surgery, laser trabeculoplasty, or laser iridotomy within 12 months of enrolment, and patients with a history of uveitis and any changes in antiglaucoma drugs in the six months before enrolment were excluded. Iridial photographs were taken by one examiner under the same conditions at one, three, and six months after the initiation of latanoprost treatment. Three glaucoma specialists, masked to patient information, independently assessed the iridial pigmentation. Cases with iridial pigmentation diagnosed by three specialists were categorized as showing a definite increase in iridial pigmentation. RESULTS: A definite increase in iridial pigmentation occurred in 3.5, 9.7, and 35.0% of eyes within one, three, and six months of treatment, respectively. Neither age, gender, nor concomitantly-used eye drops significantly influenced the incidence of iridial pigmentation within six months of instillation. The reduction of intraocular pressure by latanoprost did not differ significantly between patients with or without iridial pigmentation. CONCLUSION: The incidence of iridial pigmentation by latanoprost ophthalmic solution in Japanese patients was higher than previously reported values in pigmented races.
Dr K. Kashiwagi, Department of Ophthalmology, Yamanashi Medical University, 1110 Shimokato, Tamaho, Yamanashi 409-3898, Japan
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
