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Abstract #18397 Published in IGR 3-3
Accelerated chronic endothelial cell loss after penetrating keratoplasty in glaucoma eyes
Reinhard T; Bohringer D; Sundmacher RJournal of Glaucoma 2001; 10: 446-451
PURPOSE: Accelerated chronic endothelial cell loss may be the main reason for limited prognosis of penetrating corneal grafts in glaucoma eyes. However, this hypothesis has not yet been proven and is examined in this article. METHODS: Three groups of normal-risk keratoplasty patients were followed up prospectively. Group 1 consisted of 172 patients (without glaucoma history and without postoperative increase in intraocular pressure), group 2 comprised 15 patients (with glaucoma history, but without postoperative increase in intraocular pressure), and group 3 consisted of seven patients (with glaucoma history and a postoperative increase in intraocular pressure (IOP)). Immune reactions in the postoperative course were an exclusion criterion. Follow-up periods averaged 2.7 ± 1.7 years (group 1), 2.8 ± 1.7 years (group 2), and 2.6 ± 2.0 years (group 3). Only patients with at least three postoperative endothelial cell density values were included in the study. Loss of endothelial cells mm-2 d-1 was derived from the postoperative endothelial values of each patient by calculating the slope of the regression line for each scatterplot of endothelial cell density values plotted against time. RESULTS: During the follow-up period 0.82 ± 0.97 cells mm-2 d-1 were lost in group I, 1.01 ± 1.04 cells mm-2 d-1 were lost in group 2, 2.67 ± 2.16 cells mm-2 d-1 were lost in group 3 (ANOVA and Gabriel post-hoc test: 1/2: p = 0.82; 1/3: p < 0.001; 2/3: p = 0.004). CONCLUSIONS: Postoperative increase in IOP may be a possible cause for accelerated endothelial cell loss in glaucoma eyes, but this result is tentative because of the small number of patients included in the two glaucoma groups. Confirmation by long-term observation of larger patients groups is desirable. The results imply good control of IOP after penetrating keratoplasty. Whether this method is the correct means by which to prevent accelerated endothelial cell loss in such eyes must be shown in future studies.
Dr T. Reinhard, Lions Cornea Bank, North Rhine Westfalia and Eye Hospital, Heinrich-Heine University, Dusseldorf, Germany
Classification:
9.4.11.4 Glaucomas associated with corneal surgery (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
