advertisement
Abstract #18415 Published in IGR 3-3
Increased aqueous humor basic fibroblast growth factor and hyaluronan levels in relation to the exfoliation syndrome and exfoliative glaucoma
Gartaganis SP; Georgakopoulos CD; Exarchou AM; Mela EK; Lamari F; Karamanos NKActa Ophthalmologica Scandinavica 2001; 79: 572-575
PURPOSE: To quantify the concentrations of basic fibroblast growth factor (bFGF) and hyaluronan (HA) in the aqueous humor of patients with exfoliation syndrome (XFS) or exfoliative glaucoma (XFG). METHODS: Aqueous humor bFGF and HA levels were measured in 13 patients with XFS and in seven patients with XFG. The results were compared with those obtained from 17 healthy controls. RESULTS: Mean bFGF levels were significantly higher in the XFG patients than in the XFS patients, which in turn were higher than the bFGF levels in healthy individuals. Aqueous humor HA levels in both patients with XFS and XFG were significantly higher compared to the controls. CONCLUSIONS: The authors suggest that bFGF plays an important role in the pathogenesis of XFS and XFG, as well as in the synthesis of secreted HA, which may result in connective tissue degradation that affects the ocular anterior segment.
Dr S.P. Gartaganis, Department of Ophthalmology, University of Patras Medical School, Patras, Greece
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
