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Abstract #18448 Published in IGR 3-3
Effect of topical unoprostone on circulation of human optic nerve head and retina
Tamaki Y; Araie M; Tomita K; Nagahara M; Sandoh S; Tomidokoro AJournal of Ocular Pharmacology and Therapeutics 2001; 17: 517-527
The purpose of the present study was to study the effect of topical unoprostone on circulation in the human optic nerve head (ONH) and retina in normal subjects. Using laser-speckle tissue blood flow analysis, normalized blur (NB), a quantitative index of tissue blood velocity, was measured every 0.125 seconds at a temporal ONH site, free of visible surface vessels. Measurements were averaged for three cardiac cycles (NB(ONH)). Color Doppler imaging (CDI) was also used to evaluate peak systolic blood velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) in the central retinal artery (CRA) and mean blood velocity (MV) in the central retinal vein (CRV). For baseline comparison (Day 0), recordings of bilateral NB(ONH) and intraocular pressure (IOP), blood pressure (BP), and pulse rate (PR) were recorded in healthy volunteers before, and 45, 90, 180, and 270 minutes after instillation of one drop of unoprostone vehicle. On Day 1 (the day after baseline measurements), and twice daily for seven days, one drop of 0.12% unoprostone was instilled into one eye and its vehicle into the other, in a double-blinded manner. Measurements as on Day 0 were recorded on Days 1 and 7. CDI measurements were performed before and at 45 and 180 minutes after morning instillation on Days 1 and 7. During baseline recordings, there were no significant changes in any of the parameters. After administration of topical unoprostone, IOP was significantly lower bilaterally with more reduction in the unoprostone-treated eyes on Day 7. On Day 7, NB(ONH) of the unoprostone-treated eyes was significantly higher 45 minutes after instillation than baseline (p = 0.035 with Bonferroni's correction). Analysis of variance for repeated measurements also revealed a significant difference between Days 0 and 7 (p = 0.0017). BP, PR, and NB(ONH) in the eye that received vehicle only, PSV, EDV, and RI in the CRA of both eyes, and MV in the CRV of both eyes, changed little. Tissue blood velocity in the ONH increased, at least temporarily, following instillation of unoprostone twice daily for seven days. Although the clinical implication of the increase is unclear, the effects of topical unoprostone on human ONH circulation deserve further consideration.
Dr Y. Tamaki, Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan. tamaki-tky@umin.ac.jp
Classification:
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
