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Abstract #18449 Published in IGR 3-3
Ocular and retrobulbar blood flow in ocular hypertensives treated with topical timolol, betaxolol and carteolol
Steigerwalt RD Jr; Laurora G; Belcaro GV; Cesarone MR; De Sanctis MT; Incandela L; Minicucci RJournal of Ocular Pharmacology and Therapeutics 2001; 17: 537-544
The purpose of this study was to evaluate the effect of topical timolol 0.5%, betaxolol 0.5%, and carteolol 2% on the blood flow velocity of the central retinal artery (CRA), posterior ciliary artery (PCA), and ophthalmic artery (OA) in patients with ocular hypertension. A group of 14 patients with ocular hypertension and a group of 11 normal subjects were studied. Color Doppler was used to measure peak systolic flow velocity (PSFV) and end diastolic flow velocity (EDFV) of the CRA, PCA, and OA in the normal subjects and patients. The normal subjects were not undergoing any treatment, while the patients were studied before and after treatment with topical timolol 0.5%, betaxolol 0.5%, and carteolol 2%. In the systolic phase, there was a significant increase in the flow velocity of the CRA with all three drugs. In the diastolic phase of the CRA, the increase was significant for timolol 0.5% and carteolol 2%, but not for betaxolol 0.5%. The flow velocity of the PCA and OA remained unchanged. In this study of 14 patients with ocular hypertension, topical timolol 0.5%, betaxolol 0.5%, and carteolol 2% led to a significant increase in the flow velocity of the CRA without creating a steal or decrease in the flow velocity of the PCA.
Dr R.D. Steigerwalt Jr, Angiology and Vascular Surgery Center, San Valentino, Pescara, Italy. r.steigerwalt@libero.it
Classification:
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
