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Abstract #18455 Published in IGR 3-3
Effect of dorzolamide timolol combination versus timolol 0.5% on ocular blood flow in patients with primary open-angle glaucoma
Harris A; Jonescu-Cuypers CP; Kagemann L; Nowacki EA; Cole C; Martin BAmerican Journal of Ophthalmology 2001; 132: 490-495.
PURPOSE: Addition of dorzolamide to timolol in primary open-angle glaucoma (POAG) shows augmented reduction of intraocular pressure (IOP). It is as yet unknown whether addition of dorzolamide will alter the hemodynamics. METHODS: Fifteen patients with POAG were placed on a medication-dependent one- to four-week washout that included maintenance on timolol. After washout, baseline measurements were taken (timolol). The patients were studied after a month on timolol or dorzolamide-timolol (Cosopt®, Merck, Inc., Whitehouse Station, NJ), with the second drug preceded by another month of timolol maintenance and second baseline measurements. At each visit, visual function, IOP, and ocular hemodynamics were monitored, including indocyanine green, fluorescein angiography, and color Doppler imaging. RESULTS: Cosopt® significantly reduced IOP (14.7-13.4 mmHg, p < 0.05) and increased arteriovenous passage time (superior temporal artery) of fluorescein dye (2.13-1.76 seconds, p = 0.01), but had no effect on visual function. CONCLUSIONS: When compared with timolol in POAG, Cosopt® augments ocular tension reduction and reduces the amount of time required for blood to pass through the superior retinal vasculature.
Dr A. Harris, Letzter Chair of Ophthalmology, Indiana University School of Medicine, 702, Rotary Circle, Room 137, Indianapolis, IN 46202, USA. alharris@indiana.edu
Classification:
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
