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Abstract #18483 Published in IGR 3-3
Correlation between blue chromatic macular sensitivity and optic disc change in early glaucoma patients
Yamazaki Y; Tanaka C; Hayamizu F; Mizuki KNippon Ganka Gakkai Zasshi 2001; 105: 776-780
PURPOSE: To investigate the relationship between morphological changes of the optic nerve head (ONH) and macular sensitivity (MS) determined with blue-on-yellow (B/Y) and white-on-white (W/W) perimetry in normal subjects and patients with glaucoma. METHODS: One randomly chosen eye was evaluated in each of 28 normal subjects, 23 patients with ocular hypertension (OH), and 23 patients with early primary open-angle glaucoma (POAG). Mean values for MS by B/Y and W/W perimetry were obtained with the macular program using a modified Humphrey Field Analyzer (HFA). The Heidelberg Retina Tomograph (HRT) with software version 2.01 was used to evaluate the topographic parameters of temporal sector in ONH. RESULTS: There was no significant difference in temporal topographic parameters of ONH among the three clinical groups. Mean values for MS of B/Y and W/W perimetry in early POAG were significantly lower than in normal subjects and OH. Mean values for MS of W/W perimetry showed no significant correlation with ONH parameters of the temporal sector. In early POAG, mean values for MS of B/Y perimetry significantly correlated with cup area, cup/disc area ratio, cup volume, and rim volume in the temporal sector of ONH. CONCLUSIONS: The measurement of mean MS of B/Y might be able to detect the glaucomatous optic nerve damage due to increased intraocular pressure prior to the morphological changes of ONH in early stages of glaucoma. LA: Japanese
Dr Y. Yamazaki, Department of Ophthalmology, Nihon University School of Medicine, 30-1 Oyaguchikami-machi, Itabashi-ku, Tokyo 173-8610, Japan
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)