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Glaucoma is a common ocular disease leading to blindness. The basic pathological changes are the damage of retinal ganglion cells (RGCs) and their axons. Although there are 'intraocular pressure' and 'ocular blood flow' theories, the pathogenic mechanism of RGCs injured by glaucoma not yet clear. Recently, with the development of molecular biology, research has made great progress. The authors review current research regarding changes in ultrastructure, axonal transport, and apoptosis of RGCs injured by glaucoma. LA: Chinese
Dr X. Pan, Department of Ophthalmology, Affiliated Hospital, Qingdao Medical College, Qingdao 266003, China
1.3 Pathogenesis (Part of: 1 General aspects)