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Abstract #18920 Published in IGR 3-1
Metabolic abnormalities in patients with primary open-angle glaucoma
Elisaf M; Kitsos G; Bairaktari E; Kalaitzidis R; Kalogeropoulos C; Psilas KActa Ophthalmologica Scandinavica 2001; 79: 129-132
PURPOSE: Although there are few data on the underlying mechanisms of primary open-angle glaucoma (POAG), it has been suggested that metabolic diseases may play a role in the evolution of the disease. The authors carried out the present study to investigate the involvement of metabolic disturbances in POAG pathogenesis. MATERIAL AND METHODS: Serum metabolic parameters were evaluated in 49 POAG patients without a known history of diabetes mellitus and 72 age- and sex-matched individuals without glaucoma (control group). RESULTS: Among the metabolic parameters examined, only fasting serum glucose and uric acid levels were found significantly higher in patients with glaucoma compared to the control population (117 ± 17 mg/dl versus 105 ± 11 mg/dl, p = 0.05 and 6.2 ± 1.9 mg/dl versus 5 ± 1.2 mg/dl, p = 0.006, respectively). In addition, a considerably greater proportion of patients had disturbances of the carbohydrate metabolism and hyperuricemia. CONCLUSIONS: The authors conclude that disturbances of carbohydrate and uric acid metabolism could play a role in glaucoma damage and pathogenesis.
Dr M. Elisaf, Department of Internal Medicine, Department of Ophthalmology, Laboratory of Biochemistry, University Hospital, University of Ioannina, Ioannina, Greece
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
