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Abstract #18926 Published in IGR 3-1
Ischemic hypertension of pigeon eye
Nakabayashi MJapanese Journal of Ophthalmology 2001; 45: 128-136
PURPOSE: To determine the etiology of open-angle glaucoma in human eyes, the authors tested the hypothesis that ischemia of the endothelial cells lining Schlemm's canal alters the intraocular pressure (IOP) by affecting the transport of fluids out of the eye. METHODS: Experiments were conducted on pigeons. After blocking the two major arteries to the aqueous sinus artery of one eye by laser photocoagulation, the episcleral arteries of both eyes were cauterized. IOP was measured with a Mentor pneumatonometer before, immediately, and several days after blocking the major arteries. RESULTS: After the episcleral cauterization, IOP of the laser-treated eye rose significantly and was maintained for at least three hours. By Day 2, IOP had recovered to the pre-cauterization level. IOP of the control eye remained unchanged throughout the experiment. CONCLUSIONS: These results strongly support the hypothesis that ischemia of the endothelial cells lining Schlemm's canal plays a role in the control of the IOP.
Dr. M. Nakabayashi, Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
