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Abstract #18955 Published in IGR 3-1
Clinical significance of retinal nerve fiber layer thickness measured by optical coherence tomography in the early diagnosis of glaucoma
Liu Y; Ge J; Wang Met al.Chinese Ophthalmic Research 2000; 18: 423-426
OBJECTIVE: To evaluate the significance of retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in the early diagnosis of primary open-angle glaucoma (POAG). METHODS: Thickness of RNFL was quantified by OCT in 120 normal controls (169 eyes) and 96 patients with POAG (132 eyes). POAG cases were divided into early, advanced, and late stages. The rate of abnormal RNFL thickness was determined in each stage. The sensitivity and specificity were calculated. The relationship between RNFL thickness and visual field indices was assessed. RESULTS: RNFL was significantly thinner in each stage of glaucoma than in normal controls. The rate of abnormal RNFL thickness in the early stage of POAG was 50%, 85.29% in advanced, and 96.88% in late stage. The sensitivity was 79.55%, and specificity 80.47%. RNFL thickness was significantly correlated to visual field indices. CONCLUSIONS: RNFL becomes thinner in the early stages of glaucoma. Measuring the thickness of RNFL using OCT provides a new index for the diagnosis of glaucoma. LA: Chinese
Dr Y. Liu, Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510120, China
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)