advertisement
Abstract #19006 Published in IGR 3-1
The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study
Altan-Yaycioglu R; Turker G; Akdol S; Acunas G; Izgi BEuropean Journal of Ophthalmology 2001; 11: 37-46
PURPOSE: To evaluate the effects of four commonly used beta-blockers on ocular blood flow in patients with primary open angle glaucoma (POAG). METHODS: Eighty eyes of 40 subjects with POAG were included in the study. Subjects were randomly divided into four groups given timolol maleate 0.50%, betaxolol HCl 0.50%, carteolol 1% or levobunolol 0.50% drops, applied twice daily (one drug to each group). Before starting treatment, and at the end of the first month, ocular blood flow velocity was measured using the color Doppler imaging (CDI) method. In the ophthalmic artery (OA), central retinal artery (CRA) and temporal posterior ciliary artery (TPCA), the peak systolic (PS) and end-diastolic (ED) blood flow velocities were measured, and resistive index (RI) values were calculated. The results within each group were analyzed using the matched paired Student's t test. The data between groups were compared with one-way analysis of variance (ANOVA) and Tukey-Kramer multiple comparison tests. RESULTS: The timolol group showed a significant increase of RI values in the TPCA. In the betaxolol group, RI decreased significantly in the CRA and TPCA, whereas in the carteolol group there was a significant decrease in the CRA only. In the levobunolol group, there was no change in any of the arteries. CONCLUSIONS: Betaxolol seemed to have a greater vasodilator effect than carteolol, and levobunolol had no effect on the retinal and choroidal vasculature. Timolol may have some vasoconstrictive effect in the ciliary vasculature.
Dr R. Altan-Yaycioglu, Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Turkey. rana_yaymd@yahoo.com
Classification:
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
