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Abstract #19043 Published in IGR 3-1
Research of the relationship between the concentration of atrial natriuretic factor in aqueous humor of human eyes and primary angle-closure glaucoma
Ping L; Chunji B; Jingxin Zet al.Chinese Ophthalmic Research 2000; 18: 500-502
OBJECTIVE: To study the concentrations of atrial natriuretic factor (ANF) in human eyes as well as the relationship between ANF concentration in aqueous humor of human eyes and primary angle-closure glaucoma (PACG). METHODS: ANF concentrations were determined with radio-immunoreaction in uvea and vitreous of 22 human eyes and that in aqueous humor of ten age-related cataract patients (control eye) and 21 PACG patients. Glaucomatous eyes were represented by group A (12 cases with normal preoperative intraocular pressure) and group B (nine cases with high preoperative intraocular pressure). RESULTS: Immunoreactive ANF was detected in human aqueous humor, uvea, and vitreous. ANF concentration in the iris, ciliary, and choroid were 83 ± 28 pg/mg, 53 ± 30 pg/mg and 58 ± 32 pg/mg, respectively. The concentrations in the aqueous humor of the control group, group A, and group B were 63.6 ± 7.6 pg/ml, 118.6 ± 42.8 pg/ml, and 98 ± 29.4 pg/ml, respectively. The mean ANF concentration in the PACG group was significantly higher than that in the control group. CONCLUSIONS: Abnormal change of ANF concentration in the aqueous humor of human eyes may play an important role in pathological mechanism of PACG. LA: Chinese
Dr L. Ping, Department of Ophthalmology, First Affiliated Hospital, Nanjin Medical University, Nanjing 210029, China
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)