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Abstract #19057 Published in IGR 3-1
Enhanced ocular hypotensive response to timolol in rabbits with prior dexamethasone treatment
Schwartz B; Rom MEJournal of Ocular Pharmacology and Therapeutics 2001; 17: 27-33
The purpose of this study was to determine glucocorticoid modulation of ocular pressure to timolol applied topically to rabbit eyes that were pretreated with dexamethasone. Rabbits were pretreated with five applications of topical 0.007% of dexamethasone (0.01% dexamethasone phosphate) or saline drops, administered at ten-minute intervals. The eyes were then treated with timolol maleate drops at concentrations of free base of 0.00007, 0.0007, 0.007, and 0.07%. An additional group of rabbits received dexamethasone pretreatment only. Intraocular pressure was measured for the next four hours. Enhanced lowering of intraocular pressure was observed with dexamethasone pretreatment. Rabbits receiving the smaller dose of timolol had the least decrease in pressure. The most significant decreases in pressures occurred at 45 minutes after the administration of timolol with an average difference of 4.8 mmHg between the timolol- and dexamethasone/timolol-treated eyes for the three largest concentrations of timolol. This synergism between glucocorticoids and beta-adrenergic blockers in lowering intraocular pressure may be potentially useful in the therapy of ocular hypertension and glaucoma.
Dr. B. Schwartz, Department of Ophthalmology, Tufts University School of Medicine, 20 Park Plaza, Boston, MA 02116, USA
Classification:
9.4.1 Steroid-induced glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
