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Abstract #19108 Published in IGR 3-1
Timolol maleat hydrogel 0.1%: a prospective multicenter study
Ardjomand N; Komericki PSpektrum der Augenheilkunde 2001; 15: 9-13
BACKGROUND: Liquid solution of timolol instilled into the cul-de-sac is brought to systemic circulation within few minutes. Due to the short drug contact time with the surface, it is not possible to get the maximum concentration of the applied drug in the anterior eye segment. In this prospective study, the authors evaluated the efficacy and tolerance of a gel-forming solution of timolol maleat 0.1%. MATERIAL AND METHODS: One hundred and eleven patients (36.9% male, 63.1% female, age 64.5 ± 14.9 years) with primary open-angle glaucoma, ocular hypertension or normal-tension glaucoma, were treated with timolol maleat hydrogel 0,1% once daily over a period of three months. Intraocular pressure (IOP), tear production (Schirmer's test) and break-up-time (BUT) were evaluated. Statistical evaluation was performed using descriptive statistics. Friedman, Wilcoxon and Wilcox tests were used to evaluate statistical differences. RESULTS: The average IOP was reduced by TH-Gel in patients with antiglaucomatous pretreatment (beta-blocker) by 13.93 ± 20.41% (p < 0.001) and in patients without any pretreatment by 24.9 ± 11.96% (p < 0.001). Schirmers test raised in pretreated patients by 23.69 ± 43.8% (p < 0.001) and in not treated eyes by 33.46 ± 63.9% (p < 0.001). BUT was prolonged by 22 ± 51% (p < 0.001) in pretreated and by 11.7 ± 23% (p < 0.001) in nontreated eyes. CONCLUSIONS: Timolol maleat hydrogel 0.1% is a new and effective form of topical beta-blocker application. The advantage lies in the once-a-day application and the 0.1% concentration. The application of timolol in a gel form presents an alternative to the liquid solution, especially in patients with dry eye syndrome. LA: German
Dr N. Ardjomand, Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, W12 ONN, UK
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
