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Abstract #19109 Published in IGR 3-1
Remote results of proxopheline therapy of patients with primary open-angle glaucoma
Ermakova VN; Malinina SL; Abdulkadyrova MZVestnik Oftalmologii 2000; 116: 27-29
The effects of an original Russian combined preparation, proxofelin, consisting of 1% proxodolol and 0.25% clofelin solutions, on intraocular pressure (IOP), hydrodynamics, ocular function, arterial pressure, and heart rate, were evaluated in 42 patients (59 eyes) with primary open-angle glaucoma of up to two years' duration. Examinations were carried out before proxofelin therapy and after six, 12, 18, and 24 months of regular therapy (twice a day). Pronounced hypotensive effect on IOP (10.0 ± 0.3-11.2 ± 0.2 mmHg) was due to a significant increase (p < 0.01) in the discharge easiness coefficient (by 50-77% compared to the initial value) and suppressed production of aqueous humor (by 40-50% of the initial level). Visual acuity did not change, visual field was significantly (p < 0.05) extended during all terms of examinations, and changes in arterial pressure and heart rate during long-term therapy were negligible. The hypotensive effect of proxofelin was insufficient in 20% patients; in such cases, its combination with pilocarpin was effective. In the remainder of the patients, tolerable IOP was attained by instillation of the monopreparation. Hence, proxofelin is an effective drug for treating primary open-angle glaucoma; its efficiency is apparently due to its hypotensive action. LA: Russian
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
