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Abstract #19115 Published in IGR 3-1
Adverse effects of beta-blocker eye drops on the ocular surface
Ohtsuki M; Yokoi N; Mori K; Matsumoto Y; Adachi W; Ishibashi K; Sato M; Kinoshita SNippon Ganka Gakkai Zasshi 2001; 105: 149-154
PURPOSE: The authors investigated the adverse effects of beta-blocker eye drops on tears and ocular surface epithelium. METHODS: They studied 23 eyes of 23 glaucoma patients (ten males, 13 females: 53.8 ± 12.2 years; mean ± standard deviation) treated with beta-blocker eye drops for more than three months and 32 control subjects (16 males, 16 females: 50.4 ± 10.9). The following parameters described were compared between the groups: 1. the radius of tear meniscus curvature, 2. grades for tear lipid layer interference patterns, 3. non-invasive breakup time (N-BUT), 4. cotton thread value, 5. scores of fluorescein staining, 6. fluorescein breakup time (F-BUT), 7. scores of rose bengal staining, 8. and Schirmer I value. RESULTS: The glaucoma group showed a significant decrease in the radius of tear meniscus curvature (p = 0.0007), a significantly lower distribution in the grades for tear lipid layer interference patterns (p = 0.0270), a significant difference in the scores of fluorescein staining (p < 0.0001), a significant shortening in F-BUT (p = 0.0050), a significantly higher distribution in the scores of rose Bengal staining (p = 0.0010), and a significantly smaller value in Schirmer I value (p = 0.0042). However, there was no significant difference in N-BUT and cotton thread value. CONCLUSIONS: These results clearly demonstrate that the ocular surface in glaucoma patients treated with beta-blocker eye drops show dry-eye-like changes in terms of tears and ocular surface epithelium. LA: Japanese
Dr M. Ohtsuki, Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto 602-0841, Japan
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
