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Abstract #19117 Published in IGR 3-1
Clinical studies of D-timolol vs L-timolol
Yanhong Z; Jingzhen L; Tiansheng HChinese Ophthalmic Research 2001; 19: 52-54
OBJECTIVE: To evaluate the anti-glaucoma effect of 1% D-timolol on patients with primary open-angle glaucoma (POAG) and ocular hypertension (OH). METHODS: Thirty-six patients with POAG or OH were included. They were divided into two groups randomly for treating with either 1% D-timolol or 0.5% L-timolol twice daily. The intraocular pressure (IOP) changes and side-effects on the eyes and cardiovascular system were noted. Data of visual field and ocular blood flow were compared with the baseline after given the eyedrops for three months. RESULTS: After being given one drop of the drug, IOP dropped significantly in both groups. The IOP day curve at one month also dropped when compared with the baseline in both groups. There was no significant difference between the two drugs regarding magnitude of the hypotensive effect after three months. And the higher the IOP was, the more the IOP dropped when using D-timolol. No serious side-effects were noted. No significant change in ocular blood flow was found with color doppler imagine. Mean sensitivity of visual field was raised significantly in the D-timolol-treated group, while in the L-timolol-treated group it had not changed much. CONCLUSIONS: 1% D-timolol is a favorable eyedrop. It is effective and safe for the treatment of glaucoma. LA: Chinese
Z. Yanhong, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
